Germ To Genetic Theory

The current rage in biomedical science rests heavily on having us believe that ‘defective’ genes cause the main diseases afflicting and killing millions of Americans each year. You know the lineup: cardiovascular disease, cancer, diabetes, osteoporosis, obesity and Alzheimer’s disease. Not to mention genetic theories relative to autism, ADHD, depression, bi-polar disorder, schizophrenia and alcoholism. And, I am sure, in the near future, the disease ‘concoctions’- erectile dysfunction, restless leg syndrome, sleep disorders etc, that are marketed and sold to more and more of us each year – will also be revealed as having a genetic origin.

Isn’t it interesting that 100 years ago, almost all, if not all, of these diseases (except for alcoholism) were rarely, if ever, seen in a doctor’s office? Why is that?

Obviously, it is because our genes are not defective and are not the cause.

One would have to believe that our genetic blueprint, which hasn’t changed in 40,000 years, quite suddenly and dramatically deteriorated in the past 100 years. But genes don’t work like that; evolution takes time and selects for survival. And, if there is an obesity gene, how come obese people can lose weight, but can’t change their eye color? If it is genetic, how can type II diabetes be cured, depression overcome, and heart disease largely reversed? And how come some women with the ‘breast cancer gene’ get cancer, while others don’t? That sounds more like ‘bad luck’ than ‘bad genes.’

Genetic diseases such as Down’s syndrome, Hemophilia, Cystic Fibrosis, Sickle Cell disease and others are 100%. They affect 100% of those with abnormalities in their genes or chromosomes that occur at conception. Fortunately, they are also relatively rare.

If not ‘defective genes,’ what is it? Genetic ‘predisposition?’

Your genes are active your whole life. They are how your body interacts with our world. To that extent, everything, including all disease, is genetic. However, genes are not autonomous. They are ‘expressed,’ ‘turned-on’ or ‘off,’ in response to environmental stressors/stimuli as your body’s innate and perfect physiological adaptation response attempts to maintain balance (homeostasis), ultimately, to save your life. Predisposition is not a cause! Genetic predisposition always requires exposure to an environmental stressor – emotional, chemical or physical.

While some of us may have lower thresholds of exposure for the expression of disease, exposure is essential. For instance; they claim there is a gene for hangover that ‘predisposes’ one to hangovers. However, hangover can only occur if one drinks alcohol. Without the exposure, the hangover will never happen.

Family history is more a matter of exposure (both environment and learned behaviors) than genes. And, the environment starts in the womb.

For example; an obese mother, typically, is malnourished. The fetus’s genes adapt to this environment by creating a storage mode, thus ‘predisposing’ the baby to obesity. When born, the baby will probably grow up in a family environment with poor eating habits and a sedentary lifestyle, further encouraging obesity. It is not defective genes or programmed obesity.

We live in a toxic world that constantly assaults and taxes our genetic defenses. Some exposures, like water and air pollution, we can’t avoid. Our foods are filled with herbicides, pesticides, fungicides, antibiotics, hormones, chemical additives, preservatives, and much more. We coat ourselves with personal care products loaded with chemicals, in toothpastes, shampoos, soaps, deodorants, hairsprays, gels, make-ups, colognes, sunscreens, and more. We live in houses filled with chemical cleansers, detergents, out-gassing carpets, and paints and we work in factories or offices replete with toxins. And, we take vaccines and tons of drugs. Almost all of the above contain chemicals that are known carcinogens.

It is way too easy, convenient and profitable to blame our genes and not our environment or lifestyles. That way we have no personal responsibility or recourse. If we believe it is genetic, there is nothing we can do about it but take a pill or have surgery.

Your lifestyle has far more to do with your health than genetic predisposition. In reality, you can alter your genetic health, for better or worse, by your lifestyle choices based on the decisions you make every day in how you think, in the food choices you make and in the amount of exercise you get.

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3 Responses to “Germ To Genetic Theory”

  1. Observant Commuter says:

    April and I were discussing this same topic on our drive home Thursday night. Our society is so quick to blame obesity on genetics because an obese person’s whole family is obese. But if your grandmother raised your mother on fatty, fried and processed foods, your mother raised you on fatty, fried, processed foods, and you eat and raise your children on fatty, fried, processed foods, then that is completely environmental and not genetic!

    Love the blog so far! I will definitely be a loyal reader!

  2. Anonymous says:

    Hi, we met this morning at the coffee shop… I am really new to blogging, and I am not a geneticist, but there are a few things I would like to try and clarify.

    Disorders like Sickle Cell Anemia, Cystic Fybrosis, Down Syndrome, etc, follow the rules of single gene inheritance. They are expressions of one gene; some of these disorders are autosomal some are sex linked or sex dependant, some are dominant and some are recessive. for example, cystic fibrosis is autosomal recessive, if you have both the recessive mutant alleles, you will have CF. It is possible to have different degrees of severity, but it is a sure fact that that gene will be expressed. As for down syndrome, those who suffer from it, have 3 copies of the 21st chormosome… there is no gray area there, if you have 3 of them, you will surely have down syndrome.

    Conditions like Manic depression, schyzophrenia, possibly alcholism, depression, etc, are like our skin tone, height, and weight, they are polygenic traits that depend on the expression of many different genes. Both single gene and polygenic traits are multifactorial, which means the environment also plays a key role in the expression of the gene.
    that said, genes are still extremely influential on whether one will suffer from a certain condition or not. If i had a schyzophrenic parent, I would have a 50% chance of developing schyzophrenia. The environment surely has a say on whether i am pushed over the edge or not, but i am far more likely to develop the condition than the average american (1% chance).

    I wish i had the knowledge to write more… this is what i remember from my genetics class last semester. it’s such an interesting field! But that, according to my professor, is why certain conditions are hard to predict and seem to just run in families and pop up randomly. Environment plays an important role, but genes are still key.

    look forward to seeing you again in person!!

  3. docmay says:

    anonymous

    thank you for your considered response.

    from your comments i see we largely agree.

    your reference to schizophrenia …

    “If i had a schizophrenic parent, I would have a 50% chance of developing schizophrenia. The environment surely has a say on whether i am pushed over the edge or not, but i am far more likely to develop the condition than the average american (1% chance).”

    …is completely consistent with what i wrote:

    “genes are not autonomous. They are ‘expressed,’ ‘turned-on’ or ‘off,’ in response to environmental stressors/stimuli…Predisposition is not a cause! Genetic predisposition always requires exposure to an environmental stressor – emotional, chemical or physical.”

    I highly recommend the book “Blaming the Brain” by Elliot Valenstein. On pages 144-145:

    “Consider the evidence that schizophrenia and depression, tend to run in families. This by itself is not evidence of a genetic cause, as poverty also runs in families.”

    While there are higher incidences of schizphrenia in children of schizphrenics and, more strikingly, identical twins of schizophrenics, there are still many shared and influential environmental factors that, as you say, may “push (one) over the edge” to be schizophrenic.

    Those environmental factors can occur before birth, in gestation, growing in the womb of a schizophrenic mom and after birth, growing up in a household with a schizophrenic parent.

    “It is certainly reasonable to assume that individuals may inherit a predisposition to develop a particular mental disorder…a constitutional predisposition or tendency towards developing a particular disease, but a predisposition is only realized under certain conditions” (Blaming the Brain)

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